Rockstar Games宣布《侠盗车手：圣安地列斯》的原声CD将于11月23日上市。原声CD包括两种规格，一种是双CD的精选大碟，另一种则是8 CD的含有150首音乐的完全版大碟。

　　双CD精选版的内容有：

　　CD 1

　　The Theme From San Andreas

　　Rage Against The Machine - Killing In The Name

　　2 Pac - I Don't Give A F***

　　James Brown - The Payback

　　Ronnie Hudson - West Coast Poplock

　　Guy - Groove Me

　　Eddie Money - Two Tickets To Paradise

　　Cypress Hill - How I Could Just Kill A Man

　　The Maytals - Pressure Drop

　　Slick Rick - Children's Story

　　Rick James - Cold Blooded

　　Raze - Break 4 Love

　　CD 2

　　Ohio Players - Funky Worm

　　Heart - Barracuda

　　Compton's Most Wanted - Hood Took Me Under

　　Lyn Collins - Think About It

　　Public Enemy - Rebel Without A Pause

　　Faith No More - Midlife Crisis

　　Bell Biv Devoe - Poison

　　Max Romeo & The Upsetters - Chase The Devil

　　Eric B & Rakim - I Know You Got Soul

　　Willie Nelson - Crazy

　　Bonus Track

　　AFI - Head Like A Hole